TREATMENT OF UPPER AIRWAY ALLERGIC RESPONSES WITH A COMBINATION OF HISTAMINE RECEPTOR ANTAGONISTS

摘要

PURPOSE: A composition for the treatment of the symptoms of allergic rhinitis is provided which contains a combination of histamine receptor antagonists. CONSTITUTION: Relief from the symptoms of rhinitis is obtained by treatment with: (a)an antihistaminic effective amount of a histamine H1 receptor antagonist; together with (b) a sufficient amount of a histamine H3 receptor antagonist to provide a nasal decongestant effect. The components can be administered together in a single dosage form, or separately in the same or different dosage forms to maintain therapeutic systemic levels of both components.