ENDOPLASMIC RETICULUM STRESS TRANSCRIPTION FACTORS ATF6 AND CREB-RP

摘要

To provide a factor capable of efficiently regulating expression of an endoplasmic chaperone gene, a nucleic acid encoding it or a complementary strand nucleic acid thereof, a method for regulating expression of an endoplasmic reticulum chaperone gene, and a method for expressing a foreign gene. An endoplasmic reticulum stress transcription factor capable of regulating transcription-inducing activity, wherein the transcription-induci ng activity is exhibited by an element having the nucleotide sequence as shown in SEQ ID NO: 1 or an element having a nucleotide sequence resulting from substitution of 1 to 3 bases with other kind of bases in the nucleotide sequence as shown in SEQ ID NO: 1; a method for controlling expression of an endoplasmic reticulum chaperone, comprising expressing the factor; a method for expressing a foreign protein, comprising positively regulating expressio n of an endoplasmic reticulum chaperone gene by the method for controlling expression; a nucleic acid encoding activated form of ATF6, activated form o f CREB-RP, suppressive form of ATF6 or suppressive form of CREB-RP, or the complementary strand thereto. It is expected to be applied to treatment or prophylaxis of cancers, arteriosclerosis, cystic fibrosis, ischemic diseases , wounds or ulcers.