NUCLEOTIDE CONSTRUCT WITH OPTIMISED CODONS FOR AN HIV GENETIC VACCINE BASED ON A PRIMARY, EARLY HIV ISOLATE AND SYNTHETIC ENVELOPE

摘要

The present invention relates to a method for producing a nucleotide sequence construct with optimized codons for an HIV genetic vaccine based on a primary, early HIV isolate. Specific such nucleotide sequence construct are the synthetic envelope BX08 constructs. The invention further relates to the medical use of such constructs for the treatment and prophylaxis of HIV through DNA vaccine and for diagnostics.