| 摘要 |
A pentapeptide is disclosed having the generic formula A-A-A-B-C, wherein A is a non-polar amino acid, B is a polar amino acid, and C is a charged amino acid. In a preferred embodiment the peptide has the sequence A-Pro-Pro-B-C, and in a further preferred embodiment has the sequence of leucine-proline-proline-serine-argenine. In a most preferred embodiment, the peptide comprises at least one D-amino acid. The peptide can be extracted from the epidermis of sea cucumbers. The peptides of the present invention are useful for inhibition of tumor progression and/or inflammation in a mammal by administration from 1 milligram per kilogram body weight to 5000 milligrams per kilogram body weight. The peptide can be administered in conjunction with any suitable carriers or excipients as are known those skilled in the arts via oral delivery forms, such as in capsules, drinks, powders, rectally via suppositories, or other suitable means.
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