| 发明名称 |
METHOD FOR INHIBITING MACROPHAGE INFILTRATION USING MONOCLONAL ANTI-ALPHA-D-ANTIBODIES |
| 摘要 |
Methods to inhibit inflammation and macrophage infiltration following spinal cord injury are disclosed along with methods to modulate TNF-alpha release from cells expressing alpha-d. Anti-alpha-d monoclonal antibodies are used t o block binding between alpha-d and VCAM-1. Hybridoma secreting the antibodies are disclosed, as well as diagnostic methods using the antibodies.
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| 申请公布号 |
CA2350391(A1) |
申请公布日期 |
2000.05.25 |
| 申请号 |
CA19992350391 |
申请日期 |
1999.11.16 |
| 申请人 |
ICOS CORPORATION |
发明人 |
GALLATIN, MICHAEL W.;VAN DER VIEREN, MONICA |
| 分类号 |
G01N33/48;A61K38/00;A61K39/395;A61P1/00;A61P3/10;A61P9/10;A61P11/00;A61P11/06;A61P11/16;A61P19/02;A61P25/00;A61P31/00;C07K14/705;C07K16/28;C12N5/10;C12N15/02;C12N15/09;C12N15/12;C12P21/08;C12Q1/68;C12R1/91;G01N33/53;G01N33/577;G01N33/68;(IPC1-7):C07K16/28;C12N5/12;G01N33/566 |
主分类号 |
G01N33/48 |
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