发明名称 |
MACROLIDES WITH ANTITUMOR ACTIVITY |
摘要 |
The compound referred to herein as IB-962 12, having structure (I) can be obtained by cultivating the strain of Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can be hydrolyzed to give IB-96212B having structure (II). The sugar substituent which is L-rhodinose, can its elf be derivatized or the sugar can be replaced, in either case, giving further derivatives of IB-96212 having a group other than L-rhodinose at the position of the sugar. |
申请公布号 |
EP1001957(A1) |
申请公布日期 |
2000.05.24 |
申请号 |
EP19980937654 |
申请日期 |
1998.08.04 |
申请人 |
INSTIUTO BIOMAR S.A. |
发明人 |
CANEDO, LIBRADA MARIA;ROMERO, FRANCISCO;ESPLIEGO, FERNANDO;FERNANDEZ-PUENTES JOSE LUIS;FERNANDEZ-CHIMENO, ROSA I.;PEREZ-BAZ, JULIA |
分类号 |
A61K31/365;A61P35/00;C07D493/20;C12N1/20;C12P17/18;C12R1/29;(IPC1-7):C07D493/20 |
主分类号 |
A61K31/365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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