| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject compound suppressing the production of undesirable by-products, in one process and in a good yield, and useful as a synthetic intermediate of a trihalomethyl-substituted heterocyclic compound for a medicinal use, etc., by reacting a specific trihaloacetyl compound with a specific acetal in the presence of an organic acid, etc. SOLUTION: This method for producing a 2-(trihaloacetyl)-3-(substituted amino)-2-propenoate is provided by reacting a triacetyl compound of formula I (A is O or S; B is R, OR or the like; R is H, an alkyl or the like; X is fluoro or chloro) (preferably ethyl trifluoroacetate) with an acetal of formula II (R1, R2 are each an alkyl, an alkenyl or the like; R3, R4 are each an alkyl, a cycloalkyl or the like) (e.g.; dimethlformamidodimethylacetal) preferably at approximately 18-35 deg.C to obtain the objective compound of formula III [preferably ethyl-2-trifluoroacetyl-3-(N,N-dimethylamino)-2-propenoate.
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