| 摘要 |
This invention describes the production of bivalent linear F(ab')2 fragments comprising tandem repeats of a heavy chain fragment VH-CH1-VH-CH1 cosecreted with two light chains, so as to form two functional antigen binding sites, wherein both the C-terminus of the first CH1 is directly joined by a peptide bond to the N-terminus of the second VH.
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