Intermediates for the preparation of duocarmycin SA and derivatives thereof, and process for the production of the intermediates

摘要

PCT No. PCT/JP97/02207 Sec. 371 Date Mar. 9, 1999 Sec. 102(e) Date Mar. 9, 1999 PCT Filed Jun. 26, 1997 PCT Pub. No. WO98/12197 PCT Pub. Date Mar. 26, 1998Indole derivatives shown by the formulae (1), (2a) and (2b) (wherein R1 is a protecting group for amino group; R2 is a protecting group for hydroxyl group; R3 is a protecting group for hydroxyl group; R4 is a C1-C6 linear or branched lower alkyl group, or benzyl group), and pyrroloindole derivatives shown by formula (3) (wherein R1 is a protecting group for amino group; R2 is a protecting group for hydroxyl group; R3 is a protecting group for hydroxyl group; R4 is a C1-C6 linear or branched lower alkyl group, or benzyl group), both of which are intermediates for duocarmycin SA, which is expected to be used as an anticancer agent, and derivatives thereof; and a method for producing the same.