| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new protein which contains a specific amino acid sequence, consists of a secretory protein expressed in the lungs, the trachea, the stomach or the like and is useful is a treating and preventing agent or the like for immunological diseases, lung functional disorders, hepatic functional disorders, infectious diseases, gastrointestinal disorders or the like. SOLUTION: This protein is a new protein (salt) containing an amino acid sequence homologous or substantially homologous to the amino acid sequence represented by formula I, II or III, is expressed mainly in the lungs, the trachea, the stomach or the like and is useful as a treating and preventing agent or the like for various diseases, e.g. immunological diseases, lung functional disorders, hepatic functional disorders, infectious diseases, gastrointestinal disorders and the like. This new protein is obtained by preparing a library by means of a conventional method by the use of a genome DNA or cDNA arising from the cell and tissue of human beings or warm-blooded animals, cloning it by means of PCR method by the use of a synthetic DNA primer containing the partial base sequence of this protein and integrating the resultant gene into an expression vector to express in a host cell. |
