Process for the diagnostic assessment and monitoring, as well as medicaments for the therapy of states of shock in humans

摘要

PCT No. PCT/EP95/03881 Sec. 371 Date Jun. 3, 1997 Sec. 102(e) Date Jun. 3, 1997 PCT Filed Sep. 30, 1995 PCT Pub. No. WO96/12184 PCT Pub. Date Apr. 25, 1996A method is provided for detecting shock by measuring the concentration of cyclophilins in a patient's blood and comparing the measured concentration against a control. The severity of shock is then evaluated, an increase in cyclophilin concentrations over control levels being associated with severity. Measuring methods include enzymological techniques, such as rotomase activity assay; immunological procedures, such as radioimmunoassay and ELISA; peptide chemical processes, such as affinity chromatography; and radiochemical approaches, such as contacting the sample with radioactive cyclosporin.