Hydroxylamine derivatives and their use as metalloproteinase inhibiting agents

摘要

PCT No. PCT/EP95/01955 Sec. 371 Date Nov. 2, 1996 Sec. 102(e) Date Nov. 2, 1996 PCT Filed May 23, 1995 PCT Pub. No. WO95/33709 PCT Pub. Date Dec. 14, 1995The invention provides hydroxylamine derivatives of formula (I) wherein A, R1, R2 and R3 have the significance given in the description, which are matrix metalloproteinase inhibitors and which also prevent TNF release. They are therefore useful for the control or prevention of degenerative joints diseases such as rheumatoid arthritis and osteoarthritis or for the treatment of invasive tumours, atherosclerosis or multiple sclerosis. They can be manufactured according to generally known methods.