发明名称 Azaspiro derivatives with 5HT1B activity
摘要 PCT No. PCT/EP96/04657 Sec. 371 Date May 8, 1998 Sec. 102(e) Date May 8, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/17350 PCT Pub. Date May 15, 1997Compounds of formula (I) in which B is oxygen, CR17R18 or NR19 where R17, R18 and R19 are independently hydrogen or C1-6alkyl or B is a group S(O)b where b is 1, 2, or 3; and R6 is a group -(CH2)p-R15 where R15 is OR16 or SR16 is hydrogen or C1-6alkyl or R15 is NR10R11 where R10 and R11 are as defined for R1; have been found to exhibit 5TH1B antagonist activity.
申请公布号 US6066644(A) 申请公布日期 2000.05.23
申请号 US19980068382 申请日期 1998.05.08
申请人 SMITHKLINE BEECHAM P.L.C. 发明人 GASTER, LARAMIE MARY;WYMAN, PAUL ADRIAN
分类号 A61K31/00;A61K31/445;A61P9/00;A61P9/12;A61P15/00;A61P25/16;A61P25/22;A61P25/24;A61P43/00;C07D491/20;(IPC1-7):A61K31/435;C07D471/10;C07D487/10;C07D491/10;C07D495/10 主分类号 A61K31/00
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