| 摘要 |
PROBLEM TO BE SOLVED: To obtain an external preparation having an improved transcutaneous absorbability of a non-steroidal anti-inflammatory drug and an excellent usability by mixing oleic acid, etc., in a specific water-soluble base as a transcutaneous absorption promoter. SOLUTION: This external preparation comprises (A) a pharmaceutically- acceptable aqueous alcoholic solvent, (B) a non-steroidal anti-inflammatory drug (preferably ketoprofen, etc.), (C) oleic acid or oleyl alcohol as a trasncutaneous absorption promoter, preferably (D) menthol (especially 1-menthol) and (E) a gelling agent. Preferably the component A contains 15-70 wt.% 1-4C monohydric saturated fatty alcohol (especially ethanol, etc.), 0.1-30 wt.% polyhydric alcohol (especially 1-4C saturated fatty glycol, glycerin, etc.), and 10-60 wt.% water.
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