发明名称 |
Process for making 2-amino-2-imidazoline, guanidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives |
摘要 |
The present invention provides a process for making 2-amino-2-imidazoline, guanidine, and 2-amino-3,4,5,6-tetrahydroyrimidine derivatives by preparing the corresponding activated 2-thio-subsituted-2-derivative in a two-step, one-pot procedure and by further reacting yields this isolated derivative with the appropriate amine or its salts in the presence of a proton source. The present process allows for the preparation of 2-amino-2-imidazolines, quanidines, and 2-amino-3,4,5,6-tetrahydropyrimidines under reaction conditions that eliminate the need for lengthy, costly, or multiple low yielding steps, and highly toxic reactants. This process allows for improved yields and product purity and provides additional synthetic flexibility.
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申请公布号 |
US6066740(A) |
申请公布日期 |
2000.05.23 |
申请号 |
US19970977907 |
申请日期 |
1997.11.25 |
申请人 |
THE PROCTER & GAMBLE COMPANY |
发明人 |
GODLEWSKI, MICHAEL SELDEN;KLOPFENSTEIN, SEAN REES;MUNDLA, SREENIVASA REDDY;SEIBEL, WILLIAM LEE;MUTH, RANDY STUART |
分类号 |
C07D215/38;C07D233/50;C07D401/12;C07D403/12;C07D405/12;C07D417/12;(IPC1-7):C07D223/14;C07D223/16;C07D223/18;C07D225/24 |
主分类号 |
C07D215/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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