Amino compounds and angiotensin IV receptor agonists

摘要

PCT No. PCT/JP97/02716 Sec. 371 Date Jul. 16, 1998 Sec. 102(e) Date Jul. 16, 1998 PCT Filed Aug. 5, 1997 PCT Pub. No. WO98/05624 PCT Pub. Date Feb. 12, 1998The present invention provides an amino compound represented by Formula: wherein X is CH2NH or CONH, Y is CH2NH or CONH with the proviso that X and Y are not CONH at the same time; Z is CH=C(R4)R5, CH2CH(R4)R5 or an alkoxycarbonyl group, R1 is a hydrogen atom; a lower alkyl group, a cycloalkyl group, a cycloalkyl-substituted alkyl group, an aralkyl group or an aryl group, each group of which is substituted or unsubstituted, R2 and R3 are each independently a lower alkyl group or an aralkyl group, each group of which is substituted or unsubstituted, and R4 and R5 are each independently a hydrogen atom; an alkyl group, an aralkyl group, an aryl group or a heteroaryl group, each group of which is substituted or unsubstituted, or a pharmaceutically acceptable salt thereof; a medicine comprising the amino compound of Formula (1) or a pharmaceutically acceptable salt; and an angiotensin IV receptor agonist containing the same as an effective component, which are useful, in particular, as a therapeutical drug (antagonist or agonist) for various diseases in which angiotensin IV participates, for example, acceleration of renal blood flow, cerebral vasodilation, inhibition of cell proliferation and hypermnesia.