Modified oligonucleotides

摘要

PCT No. PCT/EP95/00156 Sec. 371 Date Nov. 12, 1996 Sec. 102(e) Date Nov. 12, 1996 PCT Filed Jan. 17, 1995 PCT Pub. No. WO95/20597 PCT Pub. Date Aug. 3, 1995Oligonucleotides of the formula: 5'(U)n-3' in which U is an identical or different radical of a natural or a synthetic nucleoside and n is a number from 2 to 200 comprising at least one structural unit of two consecutive nucleosides wherein one of the nucleotides is substituted in the 2'-position or wherein the nucleotides are substituted differently in their 2'-position and wherein the backbone is modified.