PROCESS FOR THE PREPARATION OF PAROXETINE HYDROCHLORIDE

摘要

Solid forms of paroxetine hydrochloride (crystalline as well as amorphous) are obtained by precipitation from a supercritical or near-critical fluid such as carbon dioxide. This procedure offers the advantage of a more easily controlled precipitation process than is obtained by previously known methods, and better control of surface morphology, porosity, particle size and distribution.