| 摘要 |
A compound of formula (IA) or (IB): in which R<1> is R<A>(CH2)nO(CH2)m, R<A>(CH2)p, Formula (II) or in which R is a spiro-fused mono- or bi-cyclic ring containing one or two basic nitrogen atoms; and X<1> and X<2>, which may be the same or different, are each -CH2- or -C=O, provided that at least one of X<1> and X<2> is -C=O; Y is -NH-, -CH2- or -CH2-CH2-; R<A> is an optionally substituted aryl group or heteroaryl group linked via a carbon atom; m is 1, 2 or 3; n is 0, 1 or 2; and p is 1 to 4; R<2> is vinyl or ethyl; R<3> is H, OH or F, and R<4> is H, or R<3> is H and R<4> is F. The compounds are useful for treating microbial infections in animals, especially in humans and in domesticated mammals. |
| 申请人 |
SMITHKLINE BEECHAM P.L.C.;DABBS, STEVEN;DAVIES, SUSANNAH;DEAN, DAVID, KENNETH;FRYDRYCH, COLIN, HENRY;GAIBA, ALESSANDRA;HOWARD, STEVEN;HUNT, ERIC;KING, FRANCIS, DAVID;NAYLOR, ANTOINETTE;TAKLE, ANDREW, KENNETH |
发明人 |
DABBS, STEVEN;DAVIES, SUSANNAH;DEAN, DAVID, KENNETH;FRYDRYCH, COLIN, HENRY;GAIBA, ALESSANDRA;HOWARD, STEVEN;HUNT, ERIC;KING, FRANCIS, DAVID;NAYLOR, ANTOINETTE;TAKLE, ANDREW, KENNETH |
