| 发明名称 |
NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS |
| 摘要 |
The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel pyrrolidinemethyl diamide and carbamate compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.
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| 申请公布号 |
WO0027811(A1) |
申请公布日期 |
2000.05.18 |
| 申请号 |
WO1999US26798 |
申请日期 |
1999.11.09 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
DUBOWCHIK, GENE, M.;DITTA, JONATHAN, L.;PROVENCAL, DAVID, P.;DENHART, DEREK, J. |
| 分类号 |
A61K31/40;A61K31/404;A61K31/4427;A61K31/4439;A61K31/4545;A61P25/00;A61P31/18;A61P35/00;A61P43/00;C07D207/08;C07D401/12;C07D403/12;(IPC1-7):C07D207/08;C07D211/10;A61K31/445 |
主分类号 |
A61K31/40 |
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