NEW CONTROLLED RELEASE BEAD, A METHOD OF PRODUCING THE SAME AND MULTIPLE UNIT FORMULATION COMPRISING IT
摘要
A controlled release bead comprises: (i) a core unit of a substantially water-soluble or water-swellable inert material; (ii) a first layer on the core unit of a substantially water-insoluble polymer; (iii) a second layer covering the first layer and containing an active ingredient; and (iv) a third layer of polymer on the second layer effective for controlled release of the active ingredient, wherein the first layer is adapted to control water penetration into the core. A method of producing the controlled release bead is also disclosed.
申请公布号
WO0027364(A1)
申请公布日期
2000.05.18
申请号
WO1999SE02052
申请日期
1999.11.11
申请人
PHARMACIA & UPJOHN AB;GREN, TORKEL;RINGBERG, ANDERS;WIKBERG, MARTIN;WALD, RANDY, J.
发明人
GREN, TORKEL;RINGBERG, ANDERS;WIKBERG, MARTIN;WALD, RANDY, J.