摘要 |
<p>Disclosed is a process for the preparation of oxyglutaric acid ester derivatives of the formula: <CHEM> in which each of R<1> and R<2> is alkoxy of 1-5 carbon atoms, aralkyloxy of 7-9 carbon atoms, a halogenoaralkyloxy of 7-9 carbon atoms or phenyl, R<4> is a hydroxyl-protecting group, and R<5> is alkyl of 1 to 10 carbon atoms, comprising the steps of reacting a methyl phosphonate derivative or methyl phosphine oxide derivative with an oxyglutaric acid mono-ester to give a reaction product comprising an oxyglutaric acid derivative into which a phosphorus-containing group is introduced, purifying the reaction product to isolate the oxyglutaric acid derivative, and converting the derivative into its oxyglutaric acid ester derivative.</p> |