SEPARATING AGENT, SEPARATION OF ESTROGEN COMPOUND AND ESTROGENIC SUBSTANCE, AND SCREENING, ADSORBING AND REMOVING OF ESTROGENIC SUBSTANCE

摘要

PROBLEM TO BE SOLVED: To separate estrogen compounds and estrogenic substances by reverse phase high-performance liquid chromatography by introducing a template structure to the estrogen compounds and estrogenic substances into polymer particles. SOLUTION: Estrogen compounds and/or estrogenic substances are mixed with a polymerizable monomer this monomer is polymerized and the estrogen compounds and/or estrogenic substances are removed to introduce a template structure into polymer particles. In other way, estrogen compounds and/or estrogenic substances are mixed with a linear polymer, this polymer is allowed to react with a crosslinker to form a crosslinked polymer and the estrogen compounds and/or estrogenic substances are removed. The polymer particles may be produced by seed polymerization. When the polymerizable monomer is polymerized, a multifunctional polymerizable monomer is preferably used to form a crosslinked structure.