| 摘要 |
PCT No. PCT/JP97/03228 Sec. 371 Date Feb. 3, 1999 Sec. 102(e) Date Feb. 3, 1999 PCT Filed Sep. 12, 1997 PCT Pub. No. WO97/03228 PCT Pub. Date Mar. 19, 1998A method for producing an optically active erythro-3-amino-2-hydroxybutyric ester as an important intermediate of pharmaceutical agents, specifically HIV protease inhibitor, in high purity and in high yield. The method includes producing an optically active erythro-3-amino-2-hydroxybutyric ester by oxidizing the hydroxyl group at the 2-position of an optically active 3-amino-2-hydroxybutyric ester, optically active at the 3-position, as represented by formula (I): (wherein R1 represents a phenyl group or a cyclohexyl group; R2 represents a protective group and R3 represents an unsubstituted or substituted alkyl residue; the steric configuration of *1 represents S configuration or R configuration), and then reducing erythro-selectively the resulting product by using aluminum alkoxide.
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