| 摘要 |
PCT No. PCT/US95/13715 Sec. 371 Date Jun. 27, 1997 Sec. 102(e) Date Jun. 27, 1997 PCT Filed Apr. 24, 1995 PCT Pub. No. WO96/13286 PCT Pub. Date May 9, 1996Intraocular devices which are capable of sustained release of a cell proliferation modulating agent, together with methods for their preparation and use, are provided. The proliferation modulating agent is associated either covalently or non-covalently with the material from which the intraocular device is prepared, generally a biologically inert polymer which is physiologically compatible with ocular tissue. The intraocular devices are implanted in the tissue, and the drug is released from the intraocular device such that the drug is substantially retained within the implant region. The device may be used to inhibit cellular proliferation around the implant. The device can be provided as a sterile kit, preferably in a form suitable for immediate use.
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