发明名称 |
Antiviral reagents based on RNA-binding proteins |
摘要 |
The present invention describes the generation of site-directed RNA cleaving agents. These agents consist of RNA-binding proteins, or polypeptides derived thereof, which are modified to contain a moiety capable of cleaving RNA backbones. Alternatively, the agents are oligonucleotides having nuclease resistant backbones to which a moiety capable of cleaving RNA backbones has been attached. The present invention also describes a method of cleaving target RNA substrates using the cleaving agents described herein. Further, the invention describes a method for inhibiting RNA virus expression in infected cells.
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申请公布号 |
US6063612(A) |
申请公布日期 |
2000.05.16 |
申请号 |
US19910808452 |
申请日期 |
1991.12.13 |
申请人 |
SRI INTERNATIONAL |
发明人 |
JAYASENA, SUMEDHA D.;JOHNSTON, BRIAN H. |
分类号 |
A61K38/00;C07K14/16;C12N9/16;C12N9/22;C12N15/113;C12Q1/68;(IPC1-7):C12N7/00;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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