Use of substituted (5,6) dihydronaphthalenyl compounds having retinoid-like activity to prevent or reduce ischemic injury

摘要

The present invention relates to methods of preventing, or reducing the severity of, an ischemic injury originating in an animal's dermal tissue by applying to the animal a composition comprising a compound of formula I*: or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which X is -O-CO-, -NH-CO-, -CS-NH-, -CO-O-, -CO-NH-, -COS-, -SCO-, -SCH2-, -CH2-CH2-, -CH=CH-, -C 3BOND C-, -CH2-NH-, -COCH2-, -NHCS-, -CH2S-, -CH2O-, -OCH2-, -NHCH2- or -CR5=CR6-; n is 1 or 0; Rm and Rk are independently hydrogen, halogen, C1-6 alkyl, hydroxy, C1-6 alkyloxy or nitro; R4 is -(CH2)t-Yb, C1-6 alkyl, or C3-6 cycloalkyl; R1 is -CO2Z, C1-6 alkyl, CH2OH, -CONHRy, or CHO; Ra and Rb are independently hydrogen or C1-6 alkyl, or Ra and Rb together can form a radical of the formula: Yb is naphthyl or phenyl, both radicals can be optionally substituted with one to three of C1-6 alkyl or halogen, which substituents can be the same or different; Z is hydrogen or C1-6 alkyl; R2, R3, R5, R6, and Ry are independently hydrogen or C1-6 alkyl; and t is zero to six.