Method for killing tumor and tumor associated endothelial cells using adenoviralmutants

摘要

Methods and compositions for substantially and selectively ablating cancer cells and dividing endothelial cells while substantially sparing quiescent normal cells are described consisting of replication competent adenoviral mutants that are mutant in E1A RB family member binding site region of the virus, and preferably in the E1A-CR2 region, which mutants show superior replication and efficacy compared to wild-type adenovirus in multiple tumor cell lines and in proliferating microvascular endothelial cells.