发明名称 |
Hla-a2 and hla-dr specific peptide epitopes from the melanoma antigen trp2 |
摘要 |
Novel HLA-Class I and HLA Class II restricted epitopes of the melanoma antigen tyrosinase-related protein 2 are described. A novel HLA-A*0201 restricted epitopes present in the melanoma antigen tyrosinase-related protein 2 (TRP2) is disclosed. The invention relates to a nine-amino acid peptide designated TRP2 (180-188). The peptide is demonstrated to induce cytotoxic T lymphocytes (CTL) which specifically react with, and lyse, melanoma cells in the context of HLA-A2 or HLA-A*0201. The invention further relates to a nine-amino acid peptide derived from TRP2 which induces helper T lymphocytes in the context of HLA-DR. The invention also relates to diagnostic methods and pharmaceutical compositions which employ the tumor antigen therapeutically and prophylactically. |
申请公布号 |
AU1598500(A) |
申请公布日期 |
2000.05.15 |
申请号 |
AU20000015985 |
申请日期 |
1999.10.22 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY T |
发明人 |
MARIA R. PARKHURST;STEVEN A ROSENBERG;YUTAKA KAWAKAMI;PAUL F ROBBINS |
分类号 |
A61K39/00;A61P35/00;C07K14/705 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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