Dicycloalkano {8 E,G{9 {0 tetrahydroisoindolines

摘要

Certain N-substituted tetrahydroisoindolines having cyclopentano, cyclohexano, or cycloheptano substituents in the e- and g-positions are effective antirhinoviral agents. The new compounds can be made from the appropriate dicycloalkanotetrahydrophthalic anhydrides by reaction with amines, followed by reduction; from the appropriate dicycloalkanotetrahydroisoindolines and halo compounds; or, in one particular case, from a dicycloalkanotetrahydroisoindoline and allene.