SULPHONYLATION METHOD AND REAGENT USEFUL FOR PERHALOGENATED SULPHANILIDE SYNTHESIS

摘要

The invention concerns a method and a reagent useful for the synthesis of perhalogenated sulphanilide on the carbon borne by the sulphur atom of the sulphanilide function. Said perfluoroalkane sulphonylation method is characterised in that it comprises a step which consists in contacting a nucleophile whereof the nucleophilic atom is a nitrogen, with a reagent comprising by successive or simultaneous addition a heavy sulphonyl halide, advantageously sulphonyl chloride, and an organic base comprising a metalloid atom having resonance with a pi bond, and the organic part of said sulphonyl is perhalogenated, advantageously perfluorinated, on the carbon borne by the sulphur. The invention is applicable to intermediate synthesis for organic chemistry.