NUCLEOSIDES WITH ANTI-HEPATITIS B VIRUS ACTIVITY

摘要

Compounds and pharmaceutical compositions active against hepatitis B virus a re provided, as is a method for the treatment of hepatitis B virus infection in humans and other host animals is provided comprising administering an effective amount of a .beta.-L-(2' or 3'- azido)-2',3'-dideoxy-5- fluorocytosine of formula (I) wherein R is H, acyl, monophosphate, diphosphate, or triphosphate, or a stabilized phosphate derivative (to form a stabilized nucleotide prodrug), and R' is H, acyl, or alkyl.