BOVINE CELLS EXPRESSING ADENOVIRUS ESSENTIAL FUNCTIONS FOR PROPAGATION OF RECOMBINANT ADENOVIRAL VECTORS

摘要

The invention provides cell lines capable of supporting the replication of a defective recombinant virus vector. In one aspect, bovine cell lines expressing adenovirus E1 functions are provided. The cell lines are useful for the propagation of adenovirus vectors with mutations and/or deletions in E1 and other essential regions of the adenovirus genome.