| 摘要 |
<p>An estradiol-containing adhesive preparation characterized in that 10 to 32% of the estradiol is released in 3 hours upon immersion in water at a temperature of 32±0.5 °C. The preparation preferably contains a thermoplastic elastomer, a tackifier, and a softener and/or an absorption accelerator. The elastomer preferably comprises a styrene/isoprene/styrene block copolymer and polyisobutylene. The preparation preferably comprises 0.5 to 3 wt.% estradiol, 15 to 24 wt.% styrene/isoprene/styrene block copolymer, 5.1 to 25 wt.% polyisobutylene, 26 to 40 wt.% tackifier, and 15 to 30 wt.% softener and/or 0.5 to 8 wt.% absorption accelerator.</p> |
