Medicaments for the treatment of diseases or clinical conditions featuring or characterised by bone deficiency, for example in the form of pharmaceutical compositions or incorporated into devices such as bone screws or bioresorbable implants are provided which comprise a Notch function manipulating agent which does not inhibit differentiation of progenitor or stem cells to mammalian osteoblasts.
申请公布号
WO0025809(A1)
申请公布日期
2000.05.11
申请号
WO1999GB03592
申请日期
1999.11.01
申请人
SMITH & NEPHEW PLC;SKERRY, TIMOTHY, MICHAEL;DALLAS, DONNA, JILL;WOLOWACZ, RICHARD, GREGORY