发明名称 |
ESTRADIOL-CONTAINING ADHESIVE PREPARATION |
摘要 |
An estradiol-containing adhesive preparation characterized in that 10 to 32% of the estradiol is released in 3 hours upon immersion in water at a temperature of 32+/-0.5 DEG C. The preparation preferably contains a thermoplastic elastomer, a tackifier, and a softener and/or an absorption accelerator. The elastomer preferably comprises a styrene/isoprene/styrene block copolymer and polyisobutylene. The preparation preferably comprises 0.5 to 3 wt.% estradiol, 15 to 24 wt.% styrene/isoprene/styrene block copolymer, 5.1 to 25 wt.% polyisobutylene, 26 to 40 wt.% tackifier, and 15 to 30 wt.% softener and/or 0.5 to 8 wt.% absorption accelerator.
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申请公布号 |
WO0025792(A1) |
申请公布日期 |
2000.05.11 |
申请号 |
WO1999JP05920 |
申请日期 |
1999.10.26 |
申请人 |
HISAMITSU PHARMACEUTICAL CO., INC.;SHINMURA, MIYUKI;IKEURA, YASUHIRO |
发明人 |
SHINMURA, MIYUKI;IKEURA, YASUHIRO |
分类号 |
A61K31/565;A61K9/70;A61K31/00;A61P15/00;A61P15/12;(IPC1-7):A61K31/565;C07J1/00 |
主分类号 |
A61K31/565 |
代理机构 |
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