| 发明名称 |
INHIBITORS OF PRENYL-PROTEIN TRANSFERASE |
| 摘要 |
The present invention is directed to peptidomimetic piperazine-containing macrocyclic compounds which inhibit a prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.
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| 申请公布号 |
WO0025788(A1) |
申请公布日期 |
2000.05.11 |
| 申请号 |
WO1999US24948 |
申请日期 |
1999.10.26 |
| 申请人 |
MERCK & CO., INC.;BERGMAN, JEFFREY, M. |
发明人 |
BERGMAN, JEFFREY, M. |
| 分类号 |
C07D498/18;A61K31/4985;A61P1/16;A61P9/10;A61P13/12;A61P25/00;A61P27/02;A61P31/12;A61P35/00;A61P43/00;C07D498/14;C07D498/22;(IPC1-7):A61K31/495;C07D267/00;C07D281/00;C07D291/00;C07D245/00;C07D487/22;C07D225/00;C07D513/22 |
主分类号 |
C07D498/18 |
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