| 摘要 |
In humans, approximately 60 % of expressed immunoglobulin light chains are o f the Kappa type and 40 % of the Lambda type. In mice, there is almost no Lamb da locus and over 95 % of light chains are of Kappa type. The present invention relates to transgenic mice carrying most of the human Ig Lambda light chain locus in their genome. The resulting mice express light chains with Kappa/Lambda ratio simlliar to the human ratio. Breeding of HulgL mice to Kappa-deficient mice is also described.
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