PROTEIN

摘要

A protein is described which is capable of binding to .alpha.2 macro globuli n. The protein comprises the amino acid sequence of SEQ ID No: 1 or a functiona l variant thereof. The invention also relates to a peptide comprising a fragme nt of the protein of at least six amino acids in length. A protein or peptide which is capable of generating a protective immune response to Group A streptococcus comprises the amino acid sequence of SEQ ID No: 1, a functiona l variant thereof or a functional variant of at least six amino acids in lengt h of either thereof. Such a protein or peptide may be used in a vaccine composition together with a pharmaceutically acceptable carrier.