发明名称 |
CADHERIN-11 EXPRESSION, AN ASSAY AND TREATMENT FOR CELLULAR INVASIVENESS |
摘要 |
A method of modulating differentiation or neoplastic transformation of cells is provided in which the cells are caused to increase or decrease cad-11 expression or function. Such method has application in affecting differentiation or neoplastic transformation of cells, preventing or terminating pregnancy by altering cad-11 function or expression in trophobla st cells, or for reducing the viability of carcinoma cells having a low to moderate metastatic potential. The use of agents which increase or decrease cad-11 expression or function is also provided, including such use for preparation of medicaments for modulating differentiation or neoplastic transformation of cells. A method for assessing the metastatic potential of carcinoma cells is also provided.
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申请公布号 |
CA2349835(A1) |
申请公布日期 |
2000.05.11 |
申请号 |
CA19992349835 |
申请日期 |
1999.10.29 |
申请人 |
THE UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
MACCALMAN, COLIN D. |
分类号 |
G01N33/50;A61K31/565;A61K31/57;A61K31/7088;A61K38/00;A61K39/395;A61K45/00;A61P5/30;A61P5/34;A61P15/00;A61P15/04;A61P35/00;C07K14/705;C12N5/10;C12N15/09;C12Q1/02;C12Q1/68;G01N33/15;G01N33/53;G01N33/566;(IPC1-7):C07K14/705;A61K38/17;G01N33/574 |
主分类号 |
G01N33/50 |
代理机构 |
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