ELECTROTRANSPORT DEVICE INCLUDING A COMPATIBLE ANTIMICROBIALAGENT

摘要

A transdermal electrotransport drug delivery device (10) having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. The cathode includes a cathodic electrode (24) and a cathod ic reservoir (28) comprised of a housing composed of a polymeric material and a n aqueous medium in contact with the housing. The aqueous medium includes i) a drug or an electrolyte salt or a mixture thereof and ii) a cetylpyridinium salt in an amount sufficient to inhibit microbial growth in the aqueous medium. The polymeric material is compatible with the cetylpyridinium salt. A process is also provided wherein when electric current flows from the source of electrical power so that the drug is transdermally delivered to the patie nt by electrotransport from the anodic reservoir, the cetylpyridinium salt is n ot transdermally delivered to the patient by electrotransport from the cathodic reservoir.