NOVEL COMPOSITIONS AND METHODS OF SCREENING FOR T-CELL AND B-CELL ACTIVATION MODULATORS

摘要

Described herein are proteins useful in T-cell and B-cell activation. In particular, a human SWAP70 homolog found in a T-cell library and a human RasGRP homolog are described. Also described is the binding of RasGRP to SWAP70 and the human homolog, termed JEST herein. Methods for identifying modulators of these proteins and their interactions are also described.