摘要 |
<p>Phenethylsulfones substituted α to the phenyl group with a 1-oxoisoindoline or 1,3-dioxoisoindoline reduce the levels of TNFα in a mammal. A typical embodiment is 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-aminoisoindoline-1,3-dione.</p> |