N-SUBSTITUTED (3,6-DIHYDRO)-2H-1,2-OXAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE MGLUR1 ANTAGONISTS

摘要

Use of a compound of formula (I), in which R?1, R2 and R3¿ are independently hydrogen, (C¿1?-C6)alkyl, (C2-C6)alkenyl, (C3-C10)cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted aryl (C1-C6)alkyl, unsubstituted or substituted aryl(C2-C6)alkenyl, halo, carboxy, (C1-C6)alkoxycarbonyl or (CH2)m-OH, wherein m is 1, 2 or 3; === indicates a single or double bond; X and Y are each independently hydrogen, or X and Y together represent a bridge of the formula -(CH2)n-, where n is 1 or 2, A1 and A2 are each independently an unsubstituted or substituted aryl; Z is CO-, -SO2- or -CH2-; provided that, when Z is -CO-, A1 is not 3,4,5-trimethoxyphenyl; or a pharmaceutical-acceptable salt or ester thereof, for the manufacture of a medicament for the treatment of a disorder of the CNS; and certain compounds of formula (I) per se.