发明名称 |
2-SUBSTITUTED-D-HOMOOXASTEROID DERIVATIVES |
摘要 |
Oxasteroid derivatives represented by general formula (a) which have excellent effects of inhibiting the polymerization of tubulin, inhibiting neovascularization and/or stabilizing p53 protein Zn formula (a) one of A and B represents C=O or CH2 while the other represents O; and R represents lower alkoxy. These compounds are useful in preventing or treating malignant tumor, endometriosis, chronic rheumatoid arthritis, diabetic retinopathy, ischemic heart diseases, arteriosclerosis, intractable skin ulcer, psoriasis, Kaposi's sarcoma, leproma, etc.
|
申请公布号 |
WO0026229(A1) |
申请公布日期 |
2000.05.11 |
申请号 |
WO1999JP05828 |
申请日期 |
1999.10.22 |
申请人 |
TEIKOKU HORMONE MFG. CO., LTD.;KOIZUMI, NAOYUKI;IWASHITA, SHIGEKI;KOBAYASHI, MOTOHIRO |
发明人 |
KOIZUMI, NAOYUKI;IWASHITA, SHIGEKI;KOBAYASHI, MOTOHIRO |
分类号 |
C07J63/00;(IPC1-7):C07J63/00 |
主分类号 |
C07J63/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|