摘要 |
Aryl-2-piperidones of formula (7) can be reduced to form aryl-piperidine carbinols of formula (1), which are useful in forming a variety of pharmaceutical compounds including paroxetine, in good yield and purity. Related compounds and synthesis schemes are also set forth. In said formulas, X represents a hydrogen atom, a halogen atom, a lower alkyl group, an aralkyl group, an alkoxy group, a dialkylamino group or an alkylthio group; R represents a hydrogen atom, a lower alkyl group, an aryl group, an aralkyl group, an alkoxycarbonyl group, aralkoxycarbonyl group or an aryloxycarbonyl group; and R<1> represents a hydrogen atom, a lower alkyl group, an aryl group or an aralkyl group.
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申请人 |
SYNTHON B.V. |
发明人 |
PETERS, THEODORUS, HENDRICUS, ANTONIUS;BENNEKER, FRANCISCUS, BERNARDUS, GEMMA;HOORN, HANS, JAN;PICHA, FRANTISEK |