| 摘要 |
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the structure (I) or a pharmaceutically acceptable salt thereof, wherein b is NY1 or O; c is CY2 or N; d is CY3 or N ; e is CY4 or N; f is CY5 or N; g is CY6 or N; Y4, Y5, and Y6 are independentl y hydrogen, C1-4 alkyl, or halogen; Y1 and Y2 are independently hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, NH2, OH or C1-4 alkoxy, and Y3 is hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, -CN, NH2, OH or C1-4 alkoxy; A is (II) , (III), (IV), (V) or (VI); and W, W1, R1, R3, R4, R5, X and Z are defined in the specification.
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| 申请人 |
MERCK & CO. |
发明人 |
BARROW, JAMES C.;STANTON, MATTHEW G.;BURGEY, CHRISTOPHER;LYLE, TERRY A.;DORSEY, BRUCE D.;ISAACS, RICHARD;SELNICK, HAROLD G.;MORRISSETTE, MATTHEW M.;STAAS, DONNETTE;NAYLOR-OLSEN, ADEL M.;COBURN, CRAIG;NANTERMENT, PHILIPPE G.;WILLIAMS, PETER D.;STAUFFER, KENNETH J.;SANDERSON, PHILIP E. |
