| 摘要 |
<p>FIELD: chemistry of peptides, pharmacy. SUBSTANCE: invention relates to peptide derivative of the general formula (I): X-Y-NH-(CH2)2-G or its pharmaceutically acceptable salt or its solvate where values X, Y, r, G are given in p. 1 of the invention claim. Compounds can be used for inhibition of thrombin activity in mammal. Invention describes also method of synthesis of these peptides, pharmaceutical composition and method of inhibition of thrombin activity in mammal. EFFECT: improved method of synthesis and thrombin inhibition. 6 cl, 2 tbl, 92 ex</p> |
