| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject preparation having a proper lag time from the administration of the medicine to the release of the medicine in the inside of the body, rapidly finishing the release of the medicine after the lag time, and useful in a medical field for efficient absorption or the like of the medicine by covering a specific tablet with a specified film for controlling the release of the medicine. SOLUTION: This preparation is obtained by covering (A) a tablet comprising (i) a medicine such as acetaminophen and (ii) a water-swellable material selected from a starch, a croscarmellose sodium, a carmellose calcium and a hydroxypropylcellulose having a low substitution degree, with (B) a film for controlling the release of the medicine comprising (i) 100 pts.wt. ethylcellulose and (ii) 75-1,500 pts.wt. water-insoluble powdery material (preferably talc, magnesium stearate or the like), preferably having 0.1-100μm average particle diameter. The preparation can control a lag time with good repeatability by regulating the thickness of the component B, and the kind and the added amount of the component (ii) of the component B.
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