| 摘要 |
PROBLEM TO BE SOLVED: To provide a new cycloheptimidazole derivative that has angiotensin II receptor antagonism and is useful as a therapeutic agent for hypertension or congestive heart insufficiency or as an intraocular pressure-reducing agent. SOLUTION: This compound is represented by formula I (R is a lower alkyl; R1 is tetrazole), typically (dl)-2-propyl-4-hydroxy-8-oxo-1- 2'-[(1H)-tetrazol-5- yl]biphenyl-4-yl}methyl-4,5,6,7-tetrahydrocycloheptimidazole. The compound of formula I is prepared by, for example, allowing a compound of formula II [R2 is a lower alkyl; R3 is a substituted silyl; R4 is phenyl, a (substituted) aryl] to react with a titanium compound then, with ferric chloride and a base, hydrogenating the double bond to give a compound of formula III, allowing the product of formula III to couple with a compound of formula IV (R5 is triphenylmethyl; X is a halogen) to give a compound of formula V and changing the functional groups on this product.
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